{"id":4456,"date":"2025-10-16T11:05:43","date_gmt":"2025-10-16T09:05:43","guid":{"rendered":"http:\/\/alzevit-v1.local\/?page_id=4456"},"modified":"2026-02-06T12:38:18","modified_gmt":"2026-02-06T11:38:18","slug":"alzevit","status":"publish","type":"page","link":"https:\/\/alzevit.com\/en\/alzevit\/","title":{"rendered":"L&rsquo;\u00e9tude ALZEVIT"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"4456\" class=\"elementor elementor-4456\">\n\t\t\t\t<div class=\"elementor-element elementor-element-11aec5c e-con-full e-flex e-con e-parent\" data-id=\"11aec5c\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-05c41b6 elementor-widget__width-inherit elementor-widget elementor-widget-html\" data-id=\"05c41b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n.alzevit-hero {\n  position: relative;\n  min-height: 90vh;\n  display: flex;\n  align-items: center;\n  overflow: hidden;\n  background: #00277a;\n  \/* Force pleine largeur m\u00eame dans un conteneur Elementor *\/\n  width: 100vw;\n  margin-left: calc(-50vw + 50%);\n  box-sizing: border-box;\n    margin-top: -20px;\n  padding-top: 0;\n  margin-bottom: 0;\n}\n\n.alzevit-hero-bg {\n  position: absolute;\n  top: 0;\n  left: 0;\n  width: 100%;\n  height: 100%;\n  z-index: 1;\n}\n\n.alzevit-hero-bg img {\n  width: 100%;\n  height: 100%;\n  object-fit: cover;\n  opacity: 0.35;\n}\n\n.alzevit-hero-overlay {\n  position: absolute;\n  top: 0;\n  left: 0;\n  width: 100%;\n  height: 100%;\n  background: linear-gradient(135deg, rgba(0, 39, 122, 0.92) 0%, rgba(0, 29, 92, 0.85) 50%, rgba(0, 39, 122, 0.75) 100%);\n  z-index: 2;\n}\n\n.alzevit-hero-container {\n  position: relative;\n  z-index: 3;\n  max-width: 1200px;\n  margin: 0 auto;\n  padding: 60px 40px;\n  width: 100%;\n}\n\n.alzevit-hero-content {\n  max-width: 700px;\n}\n\n.alzevit-hero-badge {\n  display: 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transparent;\n  background-clip: text;\n}\n\n.alzevit-hero-subtitle {\n  font-family: 'Inter', sans-serif;\n  font-size: 20px;\n  font-weight: 400;\n  color: rgba(255, 255, 255, 0.85);\n  line-height: 1.6;\n  margin: 0 0 40px 0;\n  max-width: 550px;\n}\n\n.alzevit-hero-cta {\n  display: flex;\n  align-items: center;\n  gap: 20px;\n  flex-wrap: wrap;\n  margin-bottom: 60px;\n}\n\n.alzevit-hero-btn {\n  display: inline-flex;\n  align-items: center;\n  gap: 10px;\n  padding: 16px 32px;\n  font-family: 'Poppins', sans-serif;\n  font-size: 16px;\n  font-weight: 600;\n  text-decoration: none;\n  border-radius: 8px;\n  transition: all 0.3s ease;\n  cursor: pointer;\n}\n\n.alzevit-hero-btn-primary {\n  background: #21cdad;\n  color: #00277a;\n  border: none;\n}\n\n.alzevit-hero-btn-primary:hover {\n  background: #1ab89a;\n  color: #00277a;\n  transform: translateY(-2px);\n  box-shadow: 0 10px 30px rgba(33, 205, 173, 0.4);\n  text-decoration: none;\n}\n\n.alzevit-hero-btn-primary:active {\n  transform: translateY(0);\n}\n\n.alzevit-hero-btn-primary svg {\n  width: 20px;\n  height: 20px;\n  transition: transform 0.3s ease;\n}\n\n.alzevit-hero-btn-primary:hover svg {\n  transform: translateX(4px);\n}\n\n.alzevit-hero-btn-secondary {\n  background: transparent;\n  color: #ffffff;\n  border: 1px solid rgba(255, 255, 255, 0.3);\n}\n\n.alzevit-hero-btn-secondary:hover {\n  background: rgba(255, 255, 255, 0.1);\n  border-color: rgba(255, 255, 255, 0.5);\n  color: #ffffff;\n  text-decoration: none;\n}\n\n\/* Statistiques *\/\n.alzevit-hero-stats {\n  display: grid;\n  grid-template-columns: repeat(3, 1fr);\n  gap: 30px;\n  padding-top: 40px;\n  border-top: 1px solid rgba(255, 255, 255, 0.15);\n}\n\n.alzevit-hero-stat {\n  text-align: left;\n}\n\n.alzevit-hero-stat-number {\n  font-family: 'Poppins', sans-serif;\n  font-size: 42px;\n  font-weight: 700;\n  color: #21cdad;\n  line-height: 1;\n  margin-bottom: 8px;\n}\n\n.alzevit-hero-stat-label {\n  font-family: 'Inter', sans-serif;\n  font-size: 14px;\n  color: rgba(255, 255, 255, 0.7);\n  line-height: 1.4;\n}\n\n\/* \u00c9l\u00e9ment d\u00e9coratif *\/\n.alzevit-hero-deco {\n  position: absolute;\n  right: -100px;\n  top: 50%;\n  transform: translateY(-50%);\n  width: 500px;\n  height: 500px;\n  border: 1px solid rgba(33, 205, 173, 0.15);\n  border-radius: 50%;\n  z-index: 2;\n  pointer-events: none;\n}\n\n.alzevit-hero-deco::before {\n  content: '';\n  position: absolute;\n  top: 50px;\n  left: 50px;\n  right: 50px;\n  bottom: 50px;\n  border: 1px solid rgba(33, 205, 173, 0.1);\n  border-radius: 50%;\n}\n\n\/* Responsive *\/\n@media (max-width: 1024px) {\n  .alzevit-hero-deco {\n    display: none;\n  }\n}\n\n@media (max-width: 768px) {\n  .alzevit-hero {\n    min-height: auto;\n    padding: 100px 0 60px;\n  }\n\n  .alzevit-hero-container {\n    padding: 40px 20px;\n  }\n\n  .alzevit-hero-title {\n    font-size: 32px;\n  }\n\n  .alzevit-hero-subtitle {\n    font-size: 17px;\n  }\n\n  .alzevit-hero-stats {\n    grid-template-columns: 1fr;\n    gap: 24px;\n  }\n\n  .alzevit-hero-stat {\n    display: flex;\n    align-items: center;\n    gap: 16px;\n  }\n\n  .alzevit-hero-stat-number {\n    font-size: 32px;\n    margin-bottom: 0;\n  }\n\n  .alzevit-hero-cta {\n    flex-direction: column;\n    align-items: stretch;\n  }\n\n  .alzevit-hero-btn {\n    justify-content: center;\n  }\n}\n<\/style>\n\n<section class=\"alzevit-hero\">\n  <!-- Image de fond -->\n  <div class=\"alzevit-hero-bg\">\n    <img decoding=\"async\" src=\"https:\/\/images.unsplash.com\/photo-1559757175-5700dde675bc?w=1920&q=80\" alt=\"Recherche m\u00e9dicale\">\n  <\/div>\n  \n  <!-- Overlay gradient -->\n  <div class=\"alzevit-hero-overlay\"><\/div>\n  \n  <!-- \u00c9l\u00e9ment d\u00e9coratif -->\n  <div class=\"alzevit-hero-deco\"><\/div>\n  \n  <div class=\"alzevit-hero-container\">\n    <div class=\"alzevit-hero-content\">\n      \n      <!-- Titre -->\n      <h1 class=\"alzevit-hero-title\">\n        ALZEVIT\n        <span>Science in the service of your memory<\/span>\n      <\/h1>\n      \n      <!-- Sous-titre -->\n      <p class=\"alzevit-hero-subtitle\">\n        Take part in creating the first national APOE registry in France. \n        A simple home saliva test to advance Alzheimer's research.\n      <\/p>\n      \n      <!-- Boutons -->\n      <div class=\"alzevit-hero-cta\">\n        <a href=\"https:\/\/inclusion.alzevit.com\/\" class=\"alzevit-hero-btn alzevit-hero-btn-primary\">\n          I want to join the study\n          <svg fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n            <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M17 8l4 4m0 0l-4 4m4-4H3\"\/>\n          <\/svg>\n        <\/a>\n        <a href=\"https:\/\/alzevit.com\/en\/about-us\/\" class=\"alzevit-hero-btn alzevit-hero-btn-secondary\">\n          Learn more\n        <\/a>\n      <\/div>\n      \n      <!-- Statistiques -->\n      <div class=\"alzevit-hero-stats\">\n        <div class=\"alzevit-hero-stat\">\n          <div class=\"alzevit-hero-stat-number\">APOE<\/div>\n          <div class=\"alzevit-hero-stat-label\">The key risk gene<br>Alzheimer's studied<\/div>\n        <\/div>\n        <div class=\"alzevit-hero-stat\">\n          <div class=\"alzevit-hero-stat-number\">50 000<\/div>\n          <div class=\"alzevit-hero-stat-label\">Participants sought<br>across France<\/div>\n        <\/div>\n        <div class=\"alzevit-hero-stat\">\n          <div class=\"alzevit-hero-stat-number\">10 min<\/div>\n          <div class=\"alzevit-hero-stat-label\">To participate<br>from the comfort of your home<\/div>\n        <\/div>\n      <\/div>\n      \n    <\/div>\n  <\/div>\n<\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t<div class=\"elementor-element elementor-element-2790b21 e-con-full e-flex e-con e-parent\" data-id=\"2790b21\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-b01c3ff elementor-widget__width-inherit elementor-widget-laptop__width-initial elementor-widget elementor-widget-html\" data-id=\"b01c3ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n.apoe-intro {\n  padding: 100px 0;\n  background: #ffffff;\n  overflow: hidden;\n}\n\n.apoe-intro-container {\n  max-width: 900px;\n  margin: 0 auto;\n  padding: 0 20px;\n}\n\n\/* Animations au scroll *\/\n.apoe-fade-up {\n  opacity: 0;\n  transform: translateY(30px);\n  transition: opacity 0.8s ease, transform 0.8s ease;\n}\n\n.apoe-fade-up.visible {\n  opacity: 1;\n  transform: translateY(0);\n}\n\n.apoe-fade-up-delay-1 { transition-delay: 0.1s; }\n.apoe-fade-up-delay-2 { transition-delay: 0.2s; }\n.apoe-fade-up-delay-3 { transition-delay: 0.3s; }\n\n.apoe-intro-eyebrow {\n  display: inline-block;\n  font-family: 'Poppins', sans-serif;\n  font-size: 14px;\n  font-weight: 600;\n  color: #21cdad;\n  text-transform: uppercase;\n  letter-spacing: 2px;\n  margin-bottom: 20px;\n  position: relative;\n  padding-left: 45px;\n}\n\n.apoe-intro-eyebrow::before {\n  content: '';\n  position: absolute;\n  left: 0;\n  top: 50%;\n  width: 32px;\n  height: 3px;\n  background: linear-gradient(90deg, #21cdad 0%, #4de8ce 100%);\n  transform: translateY(-50%);\n  border-radius: 2px;\n}\n\n.apoe-intro-title {\n  font-family: 'Poppins', sans-serif;\n  font-size: 42px;\n  font-weight: 600;\n  color: #00277a;\n  line-height: 1.2;\n  margin: 0 0 32px 0;\n}\n\n.apoe-intro-text {\n  font-family: 'Inter', sans-serif;\n  font-size: 18px;\n  line-height: 1.8;\n  color: #515468;\n  margin: 0 0 24px 0;\n}\n\n.apoe-intro-text strong {\n  color: #00277a;\n  font-weight: 600;\n}\n\n.apoe-intro-highlight {\n  margin: 50px 0;\n  padding: 35px 40px;\n  background: linear-gradient(135deg, #f8fafc 0%, #f0f4f8 100%);\n  border-radius: 12px;\n  border-left: 4px solid #21cdad;\n  position: relative;\n  overflow: hidden;\n}\n\n.apoe-intro-highlight::before {\n  content: '\"';\n  position: absolute;\n  top: 10px;\n  left: 20px;\n  font-family: 'Poppins', sans-serif;\n  font-size: 80px;\n  color: rgba(33, 205, 173, 0.1);\n  line-height: 1;\n}\n\n.apoe-intro-highlight p {\n  font-family: 'Inter', sans-serif;\n  font-size: 17px;\n  line-height: 1.75;\n  color: #00277a;\n  margin: 0;\n  font-style: italic;\n  position: relative;\n  z-index: 1;\n}\n\n@media (max-width: 768px) {\n  .apoe-intro {\n    padding: 60px 0;\n  }\n  .apoe-intro-title {\n    font-size: 30px;\n  }\n  .apoe-intro-text {\n    font-size: 16px;\n  }\n  .apoe-intro-highlight {\n    padding: 25px 20px;\n  }\n}\n<\/style>\n\n<section class=\"apoe-intro\">\n  <div class=\"apoe-intro-container\">\n    <span class=\"apoe-intro-eyebrow apoe-fade-up\">Genetic research<\/span>\n    <h2 class=\"apoe-intro-title apoe-fade-up apoe-fade-up-delay-1\">Understanding APOE and the genetics of Alzheimer's<\/h2>\n    \n    <p class=\"apoe-intro-text apoe-fade-up apoe-fade-up-delay-2\">\n      Alzheimer's disease is the most common cause of dementia. For over 30 years, \n      researchers have known that one gene plays a major role in the risk of developing this disease: <strong>APOE<\/strong>.\n    <\/p>\n    \n    <p class=\"apoe-intro-text apoe-fade-up apoe-fade-up-delay-2\">\n      Yet in France, as elsewhere, population-level data are lacking. Our study aims to fill \n      this gap by creating the <strong>first national APOE registry<\/strong>, accessible online, straightforward, \n      and based on a saliva sample taken at home.\n    <\/p>\n    \n    <div class=\"apoe-intro-highlight apoe-fade-up apoe-fade-up-delay-3\">\n      <p>\n        This registry will enable a better understanding of the distribution of APOE variants in the population, \n        advance research, and pave the way for personalised prevention strategies.\n      <\/p>\n    <\/div>\n  <\/div>\n<\/section>\n\n<script>\n\/\/ Animation au scroll\ndocument.addEventListener('DOMContentLoaded', function() {\n  const observer = new IntersectionObserver((entries) => {\n    entries.forEach(entry => {\n      if (entry.isIntersecting) {\n        entry.target.classList.add('visible');\n      }\n    });\n  }, { threshold: 0.1 });\n\n  document.querySelectorAll('.apoe-fade-up').forEach(el => {\n    observer.observe(el);\n  });\n});\n<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t<div class=\"elementor-element elementor-element-f457412 e-con-full e-flex e-con e-parent\" data-id=\"f457412\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-682f884 elementor-widget__width-inherit elementor-widget-laptop__width-initial elementor-widget elementor-widget-html\" data-id=\"682f884\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n.apoe-gene {\n  padding: 100px 0;\n  background: #f8fafc;\n  overflow: hidden;\n}\n\n.apoe-gene-container {\n  max-width: 1140px;\n  margin: 0 auto;\n  padding: 0 20px;\n}\n\n.apoe-gene-header {\n  text-align: center;\n  max-width: 750px;\n  margin: 0 auto 70px;\n}\n\n.apoe-gene-eyebrow {\n  font-family: 'Poppins', sans-serif;\n  font-size: 14px;\n  font-weight: 600;\n  color: #21cdad;\n  text-transform: uppercase;\n  letter-spacing: 2px;\n  margin-bottom: 18px;\n  display: inline-block;\n}\n\n.apoe-gene-title {\n  font-family: 'Poppins', sans-serif;\n  font-size: 42px;\n  font-weight: 600;\n  color: #00277a;\n  line-height: 1.2;\n  margin: 0 0 20px 0;\n}\n\n.apoe-gene-subtitle {\n  font-family: 'Inter', sans-serif;\n  font-size: 18px;\n  line-height: 1.7;\n  color: #515468;\n  margin: 0;\n}\n\n\/* Animations *\/\n.apoe-fade-up {\n  opacity: 0;\n  transform: translateY(30px);\n  transition: opacity 0.8s ease, transform 0.8s ease;\n}\n\n.apoe-fade-up.visible {\n  opacity: 1;\n  transform: translateY(0);\n}\n\n.apoe-scale-in {\n  opacity: 0;\n  transform: scale(0.8);\n  transition: opacity 0.6s ease, transform 0.6s ease;\n}\n\n.apoe-scale-in.visible {\n  opacity: 1;\n  transform: scale(1);\n}\n\n.apoe-delay-1 { transition-delay: 0.1s; }\n.apoe-delay-2 { transition-delay: 0.2s; }\n.apoe-delay-3 { transition-delay: 0.3s; }\n.apoe-delay-4 { transition-delay: 0.4s; }\n.apoe-delay-5 { transition-delay: 0.5s; }\n\n\/* Les 3 all\u00e8les *\/\n.apoe-alleles {\n  display: flex;\n  justify-content: center;\n  gap: 50px;\n  margin-bottom: 70px;\n  flex-wrap: wrap;\n}\n\n.apoe-allele {\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  gap: 20px;\n}\n\n.apoe-allele-circle {\n  width: 120px;\n  height: 120px;\n  border-radius: 50%;\n  display: flex;\n  align-items: center;\n  justify-content: center;\n  font-family: 'Poppins', sans-serif;\n  font-size: 32px;\n  font-weight: 700;\n  color: #ffffff;\n  position: relative;\n  transition: transform 0.4s ease, box-shadow 0.4s ease;\n  cursor: default;\n}\n\n.apoe-allele-circle::after {\n  content: '';\n  position: absolute;\n  top: -8px;\n  left: -8px;\n  right: -8px;\n  bottom: -8px;\n  border-radius: 50%;\n  border: 2px dashed transparent;\n  transition: border-color 0.4s ease, transform 0.4s ease;\n}\n\n.apoe-allele-circle:hover {\n  transform: scale(1.1);\n}\n\n.apoe-allele-circle:hover::after {\n  border-color: currentColor;\n  transform: rotate(45deg);\n}\n\n.apoe-allele-circle.e2 {\n  background: linear-gradient(135deg, #21cdad 0%, #1ab89a 100%);\n  box-shadow: 0 15px 40px rgba(33, 205, 173, 0.35);\n}\n\n.apoe-allele-circle.e2:hover::after {\n  border-color: rgba(33, 205, 173, 0.5);\n}\n\n.apoe-allele-circle.e3 {\n  background: linear-gradient(135deg, #6b7280 0%, #4b5563 100%);\n  box-shadow: 0 15px 40px rgba(107, 114, 128, 0.35);\n}\n\n.apoe-allele-circle.e3:hover::after {\n  border-color: rgba(107, 114, 128, 0.5);\n}\n\n.apoe-allele-circle.e4 {\n  background: linear-gradient(135deg, #00277a 0%, #001d5c 100%);\n  box-shadow: 0 15px 40px rgba(0, 39, 122, 0.35);\n}\n\n.apoe-allele-circle.e4:hover::after {\n  border-color: rgba(0, 39, 122, 0.5);\n}\n\n.apoe-allele-info {\n  text-align: center;\n}\n\n.apoe-allele-name {\n  font-family: 'Poppins', sans-serif;\n  font-size: 16px;\n  font-weight: 600;\n  color: #00277a;\n  margin: 0 0 4px 0;\n}\n\n.apoe-allele-desc {\n  font-family: 'Inter', sans-serif;\n  font-size: 14px;\n  color: #828599;\n}\n\n\/* Explication *\/\n.apoe-gene-explain {\n  background: #ffffff;\n  border-radius: 16px;\n  padding: 45px;\n  max-width: 850px;\n  margin: 0 auto 60px;\n  box-shadow: 0 4px 25px rgba(0, 39, 122, 0.06);\n  border: 1px solid rgba(0, 39, 122, 0.05);\n}\n\n.apoe-gene-explain p {\n  font-family: 'Inter', sans-serif;\n  font-size: 17px;\n  line-height: 1.8;\n  color: #515468;\n  margin: 0 0 16px 0;\n}\n\n.apoe-gene-explain p:last-child {\n  margin-bottom: 0;\n}\n\n.apoe-gene-explain strong {\n  color: #00277a;\n}\n\n\/* Combinaisons *\/\n.apoe-combos-wrapper {\n  text-align: center;\n}\n\n.apoe-combos-title {\n  font-family: 'Poppins', sans-serif;\n  font-size: 20px;\n  font-weight: 600;\n  color: #00277a;\n  margin-bottom: 30px;\n}\n\n.apoe-combos {\n  display: flex;\n  justify-content: center;\n  gap: 14px;\n  flex-wrap: wrap;\n}\n\n.apoe-combo {\n  display: flex;\n  align-items: center;\n  gap: 8px;\n  padding: 14px 22px;\n  background: #ffffff;\n  border-radius: 50px;\n  border: 1px solid #e5e7eb;\n  transition: all 0.3s ease;\n  cursor: default;\n}\n\n.apoe-combo:hover {\n  border-color: #21cdad;\n  box-shadow: 0 6px 20px rgba(33, 205, 173, 0.15);\n  transform: translateY(-3px);\n}\n\n.apoe-combo-dot {\n  width: 14px;\n  height: 14px;\n  border-radius: 50%;\n  transition: transform 0.3s ease;\n}\n\n.apoe-combo:hover .apoe-combo-dot {\n  transform: scale(1.2);\n}\n\n.apoe-combo-dot.e2 { background: #21cdad; }\n.apoe-combo-dot.e3 { background: #6b7280; }\n.apoe-combo-dot.e4 { background: #00277a; }\n\n.apoe-combo-text {\n  font-family: 'Inter', sans-serif;\n  font-size: 15px;\n  font-weight: 600;\n  color: #00277a;\n}\n\n@media (max-width: 768px) {\n  .apoe-gene {\n    padding: 60px 0;\n  }\n  .apoe-gene-title {\n    font-size: 30px;\n  }\n  .apoe-alleles {\n    gap: 30px;\n  }\n  .apoe-allele-circle {\n    width: 100px;\n    height: 100px;\n    font-size: 26px;\n  }\n  .apoe-gene-explain {\n    padding: 30px 25px;\n  }\n  .apoe-combos {\n    gap: 10px;\n  }\n  .apoe-combo {\n    padding: 12px 18px;\n  }\n}\n<\/style>\n\n<section class=\"apoe-gene\">\n  <div class=\"apoe-gene-container\">\n    \n    <div class=\"apoe-gene-header apoe-fade-up\">\n      <p class=\"apoe-gene-eyebrow\">The key gene<\/p>\n      <h2 class=\"apoe-gene-title\">What is the APOE gene?<\/h2>\n      <p class=\"apoe-gene-subtitle\">\n        The APOE gene (apolipoprotein E) exists in three main forms, called alleles.\n      <\/p>\n    <\/div>\n\n    <!-- Les 3 all\u00e8les -->\n    <div class=\"apoe-alleles\">\n      <div class=\"apoe-allele apoe-scale-in apoe-delay-1\">\n        <div class=\"apoe-allele-circle e2\">\u03b52<\/div>\n        <div class=\"apoe-allele-info\">\n          <p class=\"apoe-allele-name\">\u03b52 allele<\/p>\n          <span class=\"apoe-allele-desc\">Protective effect<\/span>\n        <\/div>\n      <\/div>\n      <div class=\"apoe-allele apoe-scale-in apoe-delay-2\">\n        <div class=\"apoe-allele-circle e3\">\u03b53<\/div>\n        <div class=\"apoe-allele-info\">\n          <p class=\"apoe-allele-name\">\u03b53 allele<\/p>\n          <span class=\"apoe-allele-desc\">The most common<\/span>\n        <\/div>\n      <\/div>\n      <div class=\"apoe-allele apoe-scale-in apoe-delay-3\">\n        <div class=\"apoe-allele-circle e4\">\u03b54<\/div>\n        <div class=\"apoe-allele-info\">\n          <p class=\"apoe-allele-name\">\u03b54 allele<\/p>\n          <span class=\"apoe-allele-desc\">Risk factor<\/span>\n        <\/div>\n      <\/div>\n    <\/div>\n\n    <!-- Explication -->\n    <div class=\"apoe-gene-explain apoe-fade-up apoe-delay-3\">\n      <p>\n        Each person carries <strong>two copies of the gene<\/strong> (one inherited from each parent), \n        giving rise to six possible combinations.\n      <\/p>\n      <p>\n        These variants influence the way the brain handles certain fats and proteins, \n        notably <strong>amyloid-\u03b2 protein<\/strong>, which is implicated in Alzheimer's disease.\n      <\/p>\n    <\/div>\n\n    <!-- Les 6 combinaisons -->\n    <div class=\"apoe-combos-wrapper apoe-fade-up apoe-delay-4\">\n      <p class=\"apoe-combos-title\">The 6 possible combinations<\/p>\n      <div class=\"apoe-combos\">\n        <div class=\"apoe-combo apoe-scale-in apoe-delay-1\">\n          <span class=\"apoe-combo-dot e2\"><\/span>\n          <span class=\"apoe-combo-dot e2\"><\/span>\n          <span class=\"apoe-combo-text\">\u03b52\/\u03b52<\/span>\n        <\/div>\n        <div class=\"apoe-combo apoe-scale-in apoe-delay-2\">\n          <span class=\"apoe-combo-dot e2\"><\/span>\n          <span class=\"apoe-combo-dot e3\"><\/span>\n          <span class=\"apoe-combo-text\">\u03b52\/\u03b53<\/span>\n        <\/div>\n        <div class=\"apoe-combo apoe-scale-in apoe-delay-2\">\n          <span class=\"apoe-combo-dot e3\"><\/span>\n          <span class=\"apoe-combo-dot e3\"><\/span>\n          <span class=\"apoe-combo-text\">\u03b53\/\u03b53<\/span>\n        <\/div>\n        <div class=\"apoe-combo apoe-scale-in apoe-delay-3\">\n          <span class=\"apoe-combo-dot e2\"><\/span>\n          <span class=\"apoe-combo-dot e4\"><\/span>\n          <span class=\"apoe-combo-text\">\u03b52\/\u03b54<\/span>\n        <\/div>\n        <div class=\"apoe-combo apoe-scale-in apoe-delay-3\">\n          <span class=\"apoe-combo-dot e3\"><\/span>\n          <span class=\"apoe-combo-dot e4\"><\/span>\n          <span class=\"apoe-combo-text\">\u03b53\/\u03b54<\/span>\n        <\/div>\n        <div class=\"apoe-combo apoe-scale-in apoe-delay-4\">\n          <span class=\"apoe-combo-dot e4\"><\/span>\n          <span class=\"apoe-combo-dot e4\"><\/span>\n          <span class=\"apoe-combo-text\">\u03b54\/\u03b54<\/span>\n        <\/div>\n      <\/div>\n    <\/div>\n\n  <\/div>\n<\/section>\n\n<script>\n\/\/ Animation au scroll (ajoute ce script si pas d\u00e9j\u00e0 pr\u00e9sent)\ndocument.addEventListener('DOMContentLoaded', function() {\n  const observer = new IntersectionObserver((entries) => {\n    entries.forEach(entry => {\n      if (entry.isIntersecting) {\n        entry.target.classList.add('visible');\n      }\n    });\n  }, { threshold: 0.1 });\n\n  document.querySelectorAll('.apoe-fade-up, .apoe-scale-in').forEach(el => {\n    observer.observe(el);\n  });\n});\n<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t<div class=\"elementor-element elementor-element-2a366e7 e-con-full e-flex e-con e-parent\" data-id=\"2a366e7\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-0cbafcb elementor-widget__width-inherit elementor-widget elementor-widget-html\" data-id=\"0cbafcb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n.apoe-science {\n  padding: 100px 0;\n  background: #ffffff;\n}\n\n.apoe-science-container {\n  max-width: 1000px;\n  margin: 0 auto;\n  padding: 0 20px;\n}\n\n.apoe-science-header {\n  text-align: center;\n  margin-bottom: 70px;\n}\n\n.apoe-science-eyebrow {\n  font-family: 'Poppins', sans-serif;\n  font-size: 14px;\n  font-weight: 600;\n  color: #21cdad;\n  text-transform: uppercase;\n  letter-spacing: 2px;\n  margin-bottom: 18px;\n  display: inline-block;\n}\n\n.apoe-science-title {\n  font-family: 'Poppins', sans-serif;\n  font-size: 42px;\n  font-weight: 600;\n  color: #00277a;\n  line-height: 1.2;\n  margin: 0 0 20px 0;\n}\n\n.apoe-science-intro {\n  font-family: 'Inter', sans-serif;\n  font-size: 18px;\n  line-height: 1.7;\n  color: #515468;\n  margin: 0 auto;\n  max-width: 700px;\n}\n\n\/* Sources t\u00e9l\u00e9chargeables *\/\n.apoe-science-sources {\n  display: flex;\n  justify-content: center;\n  gap: 20px;\n  margin-top: 30px;\n  flex-wrap: wrap;\n}\n\n.apoe-science-source-link {\n  display: inline-flex;\n  align-items: center;\n  gap: 10px;\n  padding: 14px 24px;\n  background: #f8fafc;\n  border: 1px solid #e5e7eb;\n  border-radius: 8px;\n  text-decoration: none;\n  transition: all 0.3s ease;\n}\n\n.apoe-science-source-link:hover {\n  background: #00277a;\n  border-color: #00277a;\n}\n\n.apoe-science-source-link:hover .apoe-science-source-icon {\n  color: #21cdad;\n}\n\n.apoe-science-source-link:hover .apoe-science-source-text {\n  color: #ffffff;\n}\n\n.apoe-science-source-icon {\n  width: 20px;\n  height: 20px;\n  color: #00277a;\n  transition: color 0.3s ease;\n}\n\n.apoe-science-source-text {\n  font-family: 'Inter', sans-serif;\n  font-size: 14px;\n  font-weight: 500;\n  color: #00277a;\n  transition: color 0.3s ease;\n}\n\n\/* Liste des d\u00e9couvertes *\/\n.apoe-science-list {\n  display: flex;\n  flex-direction: column;\n  gap: 0;\n}\n\n.apoe-science-item {\n  display: grid;\n  grid-template-columns: 80px 1fr;\n  gap: 30px;\n  padding: 40px 0;\n  border-bottom: 1px solid #e5e7eb;\n  align-items: start;\n}\n\n.apoe-science-item:first-child {\n  padding-top: 0;\n}\n\n.apoe-science-item:last-child {\n  border-bottom: none;\n  padding-bottom: 0;\n}\n\n.apoe-science-item-number {\n  font-family: 'Poppins', sans-serif;\n  font-size: 48px;\n  font-weight: 700;\n  color: #f0f1f4;\n  line-height: 1;\n}\n\n.apoe-science-item-content {\n  padding-top: 5px;\n}\n\n.apoe-science-item-title {\n  font-family: 'Poppins', sans-serif;\n  font-size: 22px;\n  font-weight: 600;\n  color: #00277a;\n  line-height: 1.3;\n  margin: 0 0 12px 0;\n}\n\n.apoe-science-item-text {\n  font-family: 'Inter', sans-serif;\n  font-size: 16px;\n  line-height: 1.75;\n  color: #515468;\n  margin: 0;\n}\n\n.apoe-science-item-stat {\n  display: inline-flex;\n  align-items: center;\n  gap: 12px;\n  margin-top: 20px;\n  padding: 12px 20px;\n  background: #f8fafc;\n  border-radius: 8px;\n}\n\n.apoe-science-item-stat-number {\n  font-family: 'Poppins', sans-serif;\n  font-size: 24px;\n  font-weight: 700;\n  color: #21cdad;\n}\n\n.apoe-science-item-stat-label {\n  font-family: 'Inter', sans-serif;\n  font-size: 14px;\n  color: #515468;\n}\n\n\/* Combo pour item 4 *\/\n.apoe-science-item-combo {\n  display: inline-flex;\n  align-items: center;\n  gap: 8px;\n  margin-top: 20px;\n  padding: 12px 20px;\n  background: #f8fafc;\n  border-radius: 8px;\n}\n\n.apoe-science-item-combo-dot {\n  width: 32px;\n  height: 32px;\n  border-radius: 50%;\n  background: #00277a;\n  display: flex;\n  align-items: center;\n  justify-content: center;\n  font-family: 'Poppins', sans-serif;\n  font-size: 11px;\n  font-weight: 600;\n  color: #ffffff;\n}\n\n.apoe-science-item-combo-label {\n  font-family: 'Inter', sans-serif;\n  font-size: 14px;\n  color: #515468;\n  margin-left: 8px;\n}\n\n@media (max-width: 768px) {\n  .apoe-science {\n    padding: 60px 0;\n  }\n  .apoe-science-title {\n    font-size: 30px;\n  }\n  .apoe-science-item {\n    grid-template-columns: 1fr;\n    gap: 15px;\n  }\n  .apoe-science-item-number {\n    font-size: 36px;\n  }\n  .apoe-science-item-title {\n    font-size: 20px;\n  }\n  .apoe-science-sources {\n    flex-direction: column;\n    align-items: center;\n  }\n}\n<\/style>\n\n<section class=\"apoe-science\">\n  <div class=\"apoe-science-container\">\n    \n    <div class=\"apoe-science-header\">\n      <p class=\"apoe-science-eyebrow\">Recent studies<\/p>\n      <h2 class=\"apoe-science-title\">APOE and Alzheimer's: what the science says<\/h2>\n      <p class=\"apoe-science-intro\">\n        Recent studies show that APOE variants are the most significant genetic factors \n        for late-onset Alzheimer's disease risk.\n      <\/p>\n      \n      <!-- Sources t\u00e9l\u00e9chargeables -->\n      <div class=\"apoe-science-sources\">\n        <a href=\"https:\/\/alzevit.com\/wp-content\/uploads\/2026\/01\/Williams-and-al.-Nature-2026.pdf\" class=\"apoe-science-source-link\" target=\"_blank\" rel=\"noopener\">\n          <svg class=\"apoe-science-source-icon\" fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n            <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M12 10v6m0 0l-3-3m3 3l3-3m2 8H7a2 2 0 01-2-2V5a2 2 0 012-2h5.586a1 1 0 01.707.293l5.414 5.414a1 1 0 01.293.707V19a2 2 0 01-2 2z\"\/>\n          <\/svg>\n          <span class=\"apoe-science-source-text\">Williams et al. npj Dementia 2026<\/span>\n        <\/a>\n        <a href=\"https:\/\/alzevit.com\/wp-content\/uploads\/2026\/01\/Fortea-2024-APOE4-homozygozity-represents-a-distinct-genetic-form-of-Alzheimers-disease2.pdf\" class=\"apoe-science-source-link\" target=\"_blank\" rel=\"noopener\">\n          <svg class=\"apoe-science-source-icon\" fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n            <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M12 10v6m0 0l-3-3m3 3l3-3m2 8H7a2 2 0 01-2-2V5a2 2 0 012-2h5.586a1 1 0 01.707.293l5.414 5.414a1 1 0 01.293.707V19a2 2 0 01-2 2z\"\/>\n          <\/svg>\n          <span class=\"apoe-science-source-text\">Fortea et al. 2024<\/span>\n        <\/a>\n      <\/div>\n    <\/div>\n\n    <!-- Liste des d\u00e9couvertes -->\n    <div class=\"apoe-science-list\">\n      \n      <!-- Item 1 -->\n      <div class=\"apoe-science-item\">\n        <div class=\"apoe-science-item-number\">01<\/div>\n        <div class=\"apoe-science-item-content\">\n          <h3 class=\"apoe-science-item-title\">The majority of cases linked to the \u03b53 and \u03b54 alleles<\/h3>\n          <p class=\"apoe-science-item-text\">\n            A study of nearly 470,000 people shows that the \u03b54 allele significantly increases risk, \n            especially in double copy. The \u03b53 allele, often considered \"neutral\", also contributes to risk compared with \u03b52.\n          <\/p>\n          <div class=\"apoe-science-item-stat\">\n            <span class=\"apoe-science-item-stat-number\">71-93%<\/span>\n            <span class=\"apoe-science-item-stat-label\">of Alzheimer's cases attributable to \u03b53 and \u03b54<\/span>\n          <\/div>\n        <\/div>\n      <\/div>\n\n      <!-- Item 2 -->\n      <div class=\"apoe-science-item\">\n        <div class=\"apoe-science-item-number\">02<\/div>\n        <div class=\"apoe-science-item-content\">\n          <h3 class=\"apoe-science-item-title\">The \u03b52 allele has a protective effect<\/h3>\n          <p class=\"apoe-science-item-text\">\n            Individuals carrying the \u03b52\/\u03b52 combination are rare in the population, \n            but have the lowest risk of developing Alzheimer's disease.\n          <\/p>\n        <\/div>\n      <\/div>\n\n      <!-- Item 3 -->\n      <div class=\"apoe-science-item\">\n        <div class=\"apoe-science-item-number\">03<\/div>\n        <div class=\"apoe-science-item-content\">\n          <h3 class=\"apoe-science-item-title\">APOE influences cerebral amyloid deposits<\/h3>\n          <p class=\"apoe-science-item-text\">\n            In the A4 study, the vast majority of amyloid deposit cases \u2014 a key marker \n            of Alzheimer's disease \u2014 were attributable to the \u03b53 and \u03b54 alleles.\n          <\/p>\n          <div class=\"apoe-science-item-stat\">\n            <span class=\"apoe-science-item-stat-number\">85%<\/span>\n            <span class=\"apoe-science-item-stat-label\">of amyloid deposits linked to \u03b53 and \u03b54<\/span>\n          <\/div>\n        <\/div>\n      <\/div>\n\n      <!-- Item 4 -->\n      <div class=\"apoe-science-item\">\n        <div class=\"apoe-science-item-number\">04<\/div>\n        <div class=\"apoe-science-item-content\">\n          <h3 class=\"apoe-science-item-title\">\u03b54\/\u03b54 represents a distinct genetic form<\/h3>\n          <p class=\"apoe-science-item-text\">\n            Individuals homozygous for \u03b54\/\u03b54 present a very high risk, an earlier age of onset, \n            and a more typical progression. This suggests that this combination could be considered \n            a specific genetic form of the disease.\n          <\/p>\n          <div class=\"apoe-science-item-combo\">\n            <div class=\"apoe-science-item-combo-dot\">\u03b54<\/div>\n            <div class=\"apoe-science-item-combo-dot\">\u03b54<\/div>\n            <span class=\"apoe-science-item-combo-label\">High-risk combination<\/span>\n          <\/div>\n        <\/div>\n      <\/div>\n\n    <\/div>\n  <\/div>\n<\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t<div class=\"elementor-element elementor-element-d0223fd e-con-full e-flex e-con e-parent\" data-id=\"d0223fd\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-25faf6c elementor-widget__width-inherit elementor-widget elementor-widget-html\" data-id=\"25faf6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n.apoe-registre {\n  padding: 80px 0;\n  background: linear-gradient(180deg, #f8fafc 0%, #ffffff 100%);\n}\n\n.apoe-registre-container {\n  max-width: 1140px;\n  margin: 0 auto;\n  padding: 0 20px;\n}\n\n.apoe-registre-header {\n  text-align: center;\n  max-width: 700px;\n  margin: 0 auto 60px;\n}\n\n.apoe-registre-eyebrow {\n  font-family: 'Poppins', sans-serif;\n  font-size: 12px;\n  font-weight: 600;\n  color: #21cdad;\n  text-transform: uppercase;\n  letter-spacing: 2px;\n  margin-bottom: 16px;\n}\n\n.apoe-registre-title {\n  font-family: 'Poppins', sans-serif;\n  font-size: 32px;\n  font-weight: 600;\n  color: #00277a;\n  line-height: 1.3;\n  margin: 0 0 20px 0;\n}\n\n.apoe-registre-subtitle {\n  font-family: 'Inter', sans-serif;\n  font-size: 16px;\n  line-height: 1.7;\n  color: #515468;\n  margin: 0;\n}\n\n\/* Layout deux colonnes *\/\n.apoe-registre-grid {\n  display: grid;\n  grid-template-columns: 1fr 1fr;\n  gap: 40px;\n  align-items: start;\n}\n\n\/* Colonne constats *\/\n.apoe-registre-constats {\n  background: #ffffff;\n  border-radius: 16px;\n  padding: 36px;\n  border: 1px solid #e5e7eb;\n}\n\n.apoe-registre-constats-title {\n  font-family: 'Poppins', sans-serif;\n  font-size: 14px;\n  font-weight: 600;\n  color: #828599;\n  text-transform: uppercase;\n  letter-spacing: 1px;\n  margin: 0 0 24px 0;\n  display: flex;\n  align-items: center;\n  gap: 10px;\n}\n\n.apoe-registre-constats-title::before {\n  content: '';\n  width: 8px;\n  height: 8px;\n  background: #e5e7eb;\n  border-radius: 50%;\n}\n\n.apoe-registre-constat {\n  display: flex;\n  gap: 16px;\n  padding: 16px 0;\n  border-bottom: 1px solid #f0f1f4;\n}\n\n.apoe-registre-constat:last-child {\n  border-bottom: none;\n  padding-bottom: 0;\n}\n\n.apoe-registre-constat-icon {\n  width: 24px;\n  height: 24px;\n  color: #828599;\n  flex-shrink: 0;\n  margin-top: 2px;\n}\n\n.apoe-registre-constat-text {\n  font-family: 'Inter', sans-serif;\n  font-size: 15px;\n  line-height: 1.6;\n  color: #515468;\n  margin: 0;\n}\n\n\/* Colonne b\u00e9n\u00e9fices *\/\n.apoe-registre-benefits {\n  background: linear-gradient(135deg, #00277a 0%, #001d5c 100%);\n  border-radius: 16px;\n  padding: 36px;\n}\n\n.apoe-registre-benefits-title {\n  font-family: 'Poppins', sans-serif;\n  font-size: 14px;\n  font-weight: 600;\n  color: rgba(255, 255, 255, 0.6);\n  text-transform: uppercase;\n  letter-spacing: 1px;\n  margin: 0 0 24px 0;\n  display: flex;\n  align-items: center;\n  gap: 10px;\n}\n\n.apoe-registre-benefits-title::before {\n  content: '';\n  width: 8px;\n  height: 8px;\n  background: #21cdad;\n  border-radius: 50%;\n}\n\n.apoe-registre-benefit {\n  display: flex;\n  gap: 16px;\n  padding: 16px 0;\n  border-bottom: 1px solid rgba(255, 255, 255, 0.1);\n}\n\n.apoe-registre-benefit:last-child {\n  border-bottom: none;\n  padding-bottom: 0;\n}\n\n.apoe-registre-benefit-icon {\n  width: 32px;\n  height: 32px;\n  background: rgba(33, 205, 173, 0.15);\n  border-radius: 8px;\n  display: flex;\n  align-items: center;\n  justify-content: center;\n  flex-shrink: 0;\n}\n\n.apoe-registre-benefit-icon svg {\n  width: 18px;\n  height: 18px;\n  color: #21cdad;\n}\n\n.apoe-registre-benefit-content {\n  flex: 1;\n}\n\n.apoe-registre-benefit-label {\n  font-family: 'Poppins', sans-serif;\n  font-size: 16px;\n  font-weight: 600;\n  color: #ffffff;\n  margin: 0 0 6px 0;\n}\n\n.apoe-registre-benefit-text {\n  font-family: 'Inter', sans-serif;\n  font-size: 14px;\n  line-height: 1.6;\n  color: rgba(255, 255, 255, 0.7);\n  margin: 0;\n}\n\n\/* Footer de section *\/\n.apoe-registre-footer {\n  margin-top: 50px;\n  text-align: center;\n  padding: 32px;\n  background: #ffffff;\n  border-radius: 12px;\n  border: 2px solid #21cdad;\n}\n\n.apoe-registre-footer-text {\n  font-family: 'Inter', sans-serif;\n  font-size: 17px;\n  line-height: 1.6;\n  color: #00277a;\n  margin: 0;\n  font-weight: 500;\n}\n\n.apoe-registre-footer-text strong {\n  color: #21cdad;\n}\n\n@media (max-width: 768px) {\n  .apoe-registre {\n    padding: 50px 0;\n  }\n  .apoe-registre-title {\n    font-size: 26px;\n  }\n  .apoe-registre-grid {\n    grid-template-columns: 1fr;\n    gap: 24px;\n  }\n  .apoe-registre-constats,\n  .apoe-registre-benefits {\n    padding: 28px;\n  }\n}\n<\/style>\n\n<section class=\"apoe-registre\">\n  <div class=\"apoe-registre-container\">\n    \n    <div class=\"apoe-registre-header\">\n      <p class=\"apoe-registre-eyebrow\">Our mission<\/p>\n      <h2 class=\"apoe-registre-title\">Why create a national APOE registry?<\/h2>\n      <p class=\"apoe-registre-subtitle\">\n        Despite the importance of APOE in Alzheimer's risk, major gaps remain. \n        A national registry would help address them.\n      <\/p>\n    <\/div>\n\n    <div class=\"apoe-registre-grid\">\n      \n      <!-- Colonne Constats -->\n      <div class=\"apoe-registre-constats\">\n        <h3 class=\"apoe-registre-constats-title\">In France today<\/h3>\n        \n        <div class=\"apoe-registre-constat\">\n          <svg class=\"apoe-registre-constat-icon\" fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n            <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M18.364 18.364A9 9 0 005.636 5.636m12.728 12.728A9 9 0 015.636 5.636m12.728 12.728L5.636 5.636\"\/>\n          <\/svg>\n          <p class=\"apoe-registre-constat-text\">\n            The <strong>national data are non-existent<\/strong> on the distribution of APOE variants in the population.\n          <\/p>\n        <\/div>\n\n        <div class=\"apoe-registre-constat\">\n          <svg class=\"apoe-registre-constat-icon\" fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n            <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M8.228 9c.549-1.165 2.03-2 3.772-2 2.21 0 4 1.343 4 3 0 1.4-1.278 2.575-3.006 2.907-.542.104-.994.54-.994 1.093m0 3h.01M21 12a9 9 0 11-18 0 9 9 0 0118 0z\"\/>\n          <\/svg>\n          <p class=\"apoe-registre-constat-text\">\n            The <strong>clinical trials<\/strong> need to better identify at-risk individuals in order to progress.\n          <\/p>\n        <\/div>\n\n        <div class=\"apoe-registre-constat\">\n          <svg class=\"apoe-registre-constat-icon\" fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n            <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M12 8v4m0 4h.01M21 12a9 9 0 11-18 0 9 9 0 0118 0z\"\/>\n          <\/svg>\n          <p class=\"apoe-registre-constat-text\">\n            The <strong>personalised prevention strategies<\/strong> require a better understanding of the population.\n          <\/p>\n        <\/div>\n      <\/div>\n\n      <!-- Colonne B\u00e9n\u00e9fices -->\n      <div class=\"apoe-registre-benefits\">\n        <h3 class=\"apoe-registre-benefits-title\">What the registry will enable<\/h3>\n        \n        <div class=\"apoe-registre-benefit\">\n          <div class=\"apoe-registre-benefit-icon\">\n            <svg fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n              <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M9 19v-6a2 2 0 00-2-2H5a2 2 0 00-2 2v6a2 2 0 002 2h2a2 2 0 002-2zm0 0V9a2 2 0 012-2h2a2 2 0 012 2v10m-6 0a2 2 0 002 2h2a2 2 0 002-2m0 0V5a2 2 0 012-2h2a2 2 0 012 2v14a2 2 0 01-2 2h-2a2 2 0 01-2-2z\"\/>\n            <\/svg>\n          <\/div>\n          <div class=\"apoe-registre-benefit-content\">\n            <p class=\"apoe-registre-benefit-label\">Advance research<\/p>\n            <p class=\"apoe-registre-benefit-text\">Understand the distribution of APOE variants in the French population.<\/p>\n          <\/div>\n        <\/div>\n\n        <div class=\"apoe-registre-benefit\">\n          <div class=\"apoe-registre-benefit-icon\">\n            <svg fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n              <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M15 12a3 3 0 11-6 0 3 3 0 016 0z\"\/>\n              <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M2.458 12C3.732 7.943 7.523 5 12 5c4.478 0 8.268 2.943 9.542 7-1.274 4.057-5.064 7-9.542 7-4.477 0-8.268-2.943-9.542-7z\"\/>\n            <\/svg>\n          <\/div>\n          <div class=\"apoe-registre-benefit-content\">\n            <p class=\"apoe-registre-benefit-label\">Identify earlier<\/p>\n            <p class=\"apoe-registre-benefit-text\">Offer tailored follow-up or participation in prevention studies.<\/p>\n          <\/div>\n        <\/div>\n\n        <div class=\"apoe-registre-benefit\">\n          <div class=\"apoe-registre-benefit-icon\">\n            <svg fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n              <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M19.428 15.428a2 2 0 00-1.022-.547l-2.387-.477a6 6 0 00-3.86.517l-.318.158a6 6 0 01-3.86.517L6.05 15.21a2 2 0 00-1.806.547M8 4h8l-1 1v5.172a2 2 0 00.586 1.414l5 5c1.26 1.26.367 3.414-1.415 3.414H4.828c-1.782 0-2.674-2.154-1.414-3.414l5-5A2 2 0 009 10.172V5L8 4z\"\/>\n            <\/svg>\n          <\/div>\n          <div class=\"apoe-registre-benefit-content\">\n            <p class=\"apoe-registre-benefit-label\">Prepare for precision medicine<\/p>\n            <p class=\"apoe-registre-benefit-text\">Future treatments may target \u03b54\/\u03b54, \u03b53\/\u03b54 carriers differently, etc.<\/p>\n          <\/div>\n        <\/div>\n\n        <div class=\"apoe-registre-benefit\">\n          <div class=\"apoe-registre-benefit-icon\">\n            <svg fill=\"none\" stroke=\"currentColor\" viewbox=\"0 0 24 24\">\n              <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M3.055 11H5a2 2 0 012 2v1a2 2 0 002 2 2 2 0 012 2v2.945M8 3.935V5.5A2.5 2.5 0 0010.5 8h.5a2 2 0 012 2 2 2 0 104 0 2 2 0 012-2h1.064M15 20.488V18a2 2 0 012-2h3.064M21 12a9 9 0 11-18 0 9 9 0 0118 0z\"\/>\n            <\/svg>\n          <\/div>\n          <div class=\"apoe-registre-benefit-content\">\n            <p class=\"apoe-registre-benefit-label\">Understand the real impact<\/p>\n            <p class=\"apoe-registre-benefit-text\">At the scale of an entire country \u2014 something that has never been done before.<\/p>\n          <\/div>\n        <\/div>\n      <\/div>\n\n    <\/div>\n\n  <\/div>\n<\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t<div class=\"elementor-element elementor-element-cc9135b e-flex e-con-boxed e-con e-parent\" data-id=\"cc9135b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\r\n\t\t\t\t\t<div class=\"e-con-inner\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-921ba3a cms-heading-layout-2 elementor-widget elementor-widget-cms_heading\" data-id=\"921ba3a\" data-element_type=\"widget\" data-e-type=\"widget\" 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Join the 50,000 volunteers helping science to make progress against Alzheimer's disease.<\/p>\r\n    <div class=\"extra-space clearfix\"> <\/div>\r\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-83ba5ac e-con-full e-flex e-con e-child\" data-id=\"83ba5ac\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-a3a9fd9 elementor-widget elementor-widget-cms_button\" data-id=\"a3a9fd9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"cms_button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div class=\"cms-btn-wraps  text-\" >\r\n                <a href=\"https:\/\/inclusion.alzevit.com\/\" class=\"btn btn-fill btn-white text-darken-accent btn-hover-fill btn-hover-primary text-hover-white btn-lg btn-no-icon\">\r\n                <span class=\"cms-btn-content cms-btn-content- justify-content-center\">\r\n                                        <span class=\"cms-btn-text text-center\">Join <\/span>\r\n                                    <\/span>\r\n            <\/a>\r\n                <\/div>\r\n    \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7daf1f elementor-widget elementor-widget-cms_button\" data-id=\"b7daf1f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"cms_button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div class=\"cms-btn-wraps  text-\" >\r\n                <a href=\"https:\/\/alzevit.com\/en\/help-faqs\/\" class=\"btn btn-outline btn-white text-white btn-hover-fill btn-hover-primary text-hover-white btn-lg btn-no-icon\">\r\n                <span class=\"cms-btn-content cms-btn-content- justify-content-center\">\r\n                                        <span class=\"cms-btn-text text-center\">Read the FAQ<\/span>\r\n                                    <\/span>\r\n            <\/a>\r\n                <\/div>\r\n    \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>ALZEVIT La science au service de votre m\u00e9moire Participez \u00e0 la cr\u00e9ation du premier registre national APOE en France. Un simple pr\u00e9l\u00e8vement salivaire \u00e0 domicile pour faire avancer la recherche sur Alzheimer. Je participe \u00e0 l&rsquo;\u00e9tude En savoir plus APOE Le g\u00e8ne cl\u00e9 du risqueAlzheimer \u00e9tudi\u00e9 50 000 Participants recherch\u00e9spartout en France 10 min Pour participerdepuis chez vous Recherche g\u00e9n\u00e9tique Comprendre APOE et la g\u00e9n\u00e9tique d&rsquo;Alzheimer La maladie d&rsquo;Alzheimer est la cause la plus fr\u00e9quente de d\u00e9mence. Depuis plus de 30 ans, les chercheurs savent qu&rsquo;un g\u00e8ne joue un r\u00f4le majeur dans le risque de d\u00e9velopper cette maladie : APOE. Pourtant, en France comme ailleurs, les donn\u00e9es populationnelles manquent. Notre \u00e9tude vise \u00e0 combler ce manque en cr\u00e9ant le premier registre national APOE, accessible en ligne, simple, et bas\u00e9 sur un pr\u00e9l\u00e8vement salivaire r\u00e9alis\u00e9 \u00e0 domicile. Ce registre permettra de mieux comprendre la distribution des variants APOE dans la population, d&rsquo;am\u00e9liorer la recherche, et d&rsquo;ouvrir la voie \u00e0 des strat\u00e9gies de pr\u00e9vention personnalis\u00e9es. Le g\u00e8ne cl\u00e9 Qu&rsquo;est-ce que le g\u00e8ne APOE ? Le g\u00e8ne APOE (apolipoprot\u00e9ine E) existe sous trois formes principales, appel\u00e9es all\u00e8les. \u03b52 All\u00e8le \u03b52 Effet protecteur \u03b53 All\u00e8le \u03b53 Le plus courant \u03b54 All\u00e8le \u03b54 Facteur de risque Chaque personne poss\u00e8de deux copies du g\u00e8ne (une h\u00e9rit\u00e9e de chaque parent), ce qui donne six combinaisons possibles. Ces variantes influencent la mani\u00e8re dont le cerveau g\u00e8re certaines graisses et prot\u00e9ines, notamment la prot\u00e9ine amylo\u00efde-\u03b2, impliqu\u00e9e dans la maladie d&rsquo;Alzheimer. Les 6 combinaisons possibles \u03b52\/\u03b52 \u03b52\/\u03b53 \u03b53\/\u03b53 \u03b52\/\u03b54 \u03b53\/\u03b54 \u03b54\/\u03b54 \u00c9tudes r\u00e9centes APOE et Alzheimer : ce que dit la science Les \u00e9tudes r\u00e9centes montrent que les variants APOE sont les facteurs g\u00e9n\u00e9tiques les plus importants du risque de maladie d&rsquo;Alzheimer tardive. Williams et al. npj Dementia 2026 Fortea et al. 2024 01 La majorit\u00e9 des cas li\u00e9s aux all\u00e8les \u03b53 et \u03b54 Une \u00e9tude sur pr\u00e8s de 470 000 personnes montre que l&rsquo;all\u00e8le \u03b54 augmente fortement le risque, surtout en double copie. L&rsquo;all\u00e8le \u03b53, souvent consid\u00e9r\u00e9 comme \u00ab\u00a0neutre\u00a0\u00bb, contribue aussi au risque compar\u00e9 \u00e0 \u03b52. 71-93% des cas d&rsquo;Alzheimer attribuables \u00e0 \u03b53 et \u03b54 02 L&rsquo;all\u00e8le \u03b52 a un effet protecteur Les personnes porteuses de la combinaison \u03b52\/\u03b52 sont rares dans la population, mais pr\u00e9sentent le risque le plus faible de d\u00e9velopper la maladie d&rsquo;Alzheimer. 03 APOE influence les d\u00e9p\u00f4ts amylo\u00efdes c\u00e9r\u00e9braux Dans l&rsquo;\u00e9tude A4, la grande majorit\u00e9 des cas de d\u00e9p\u00f4ts amylo\u00efdes \u2014 un marqueur cl\u00e9 de la maladie d&rsquo;Alzheimer \u2014 \u00e9taient attribuables aux all\u00e8les \u03b53 et \u03b54. 85% des d\u00e9p\u00f4ts amylo\u00efdes li\u00e9s \u00e0 \u03b53 et \u03b54 04 \u03b54\/\u03b54 repr\u00e9sente une forme g\u00e9n\u00e9tique distincte Les personnes homozygotes \u03b54\/\u03b54 pr\u00e9sentent un risque tr\u00e8s \u00e9lev\u00e9, un \u00e2ge de d\u00e9but plus pr\u00e9coce, et une progression plus typique. Cela sugg\u00e8re que cette combinaison pourrait \u00eatre consid\u00e9r\u00e9e comme une forme g\u00e9n\u00e9tique sp\u00e9cifique de la maladie. \u03b54 \u03b54 Combinaison \u00e0 risque \u00e9lev\u00e9 Notre mission Pourquoi cr\u00e9er un registre national APOE ? Malgr\u00e9 l&rsquo;importance d&rsquo;APOE dans le risque d&rsquo;Alzheimer, des lacunes majeures persistent. Un registre national permettrait d&rsquo;y r\u00e9pondre. Aujourd&rsquo;hui en France Les donn\u00e9es nationales sont inexistantes sur la distribution des variants APOE dans la population. Les essais cliniques ont besoin de mieux identifier les personnes \u00e0 risque pour avancer. Les strat\u00e9gies de pr\u00e9vention personnalis\u00e9e n\u00e9cessitent une meilleure compr\u00e9hension de la population. Ce que le registre permettra Am\u00e9liorer la recherche Comprendre la distribution des variants APOE dans la population fran\u00e7aise. Identifier plus t\u00f4t Proposer un suivi adapt\u00e9 ou une participation \u00e0 des \u00e9tudes de pr\u00e9vention. Pr\u00e9parer la m\u00e9decine de pr\u00e9cision Les futurs traitements pourraient cibler diff\u00e9remment les personnes \u03b54\/\u03b54, \u03b53\/\u03b54, etc. Comprendre l&rsquo;impact r\u00e9el \u00c0 l&rsquo;\u00e9chelle d&rsquo;un pays, ce qui n&rsquo;a encore jamais \u00e9t\u00e9 fait. Participez \u00e0 l&rsquo;avanc\u00e9e de la recherche Votre participation est pr\u00e9cieuse. Rejoignez les 50 000 volontaires qui aident la science \u00e0 progresser contre la maladie d&rsquo;Alzheimer. Je participe Lire la FAQ<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4456","page","type-page","status-publish","hentry","cms-no-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/alzevit.com\/en\/wp-json\/wp\/v2\/pages\/4456","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alzevit.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/alzevit.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/alzevit.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/alzevit.com\/en\/wp-json\/wp\/v2\/comments?post=4456"}],"version-history":[{"count":316,"href":"https:\/\/alzevit.com\/en\/wp-json\/wp\/v2\/pages\/4456\/revisions"}],"predecessor-version":[{"id":5499,"href":"https:\/\/alzevit.com\/en\/wp-json\/wp\/v2\/pages\/4456\/revisions\/5499"}],"wp:attachment":[{"href":"https:\/\/alzevit.com\/en\/wp-json\/wp\/v2\/media?parent=4456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}